PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma.

  title={PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma.},
  author={Tingting Sun and Ngai Na Co and Nathalie Wong},
  journal={Biochemical and biophysical research communications},
  volume={449 1},
PFTK1 is a Cdc2-related protein kinase that is frequently upregulated in human hepatocellular carcinoma (HCC) where it correlates with metastatic features and motile phenotypes. To understand the modulated pathway underlining the PFTK1 action, here we show a physical interaction between PFTK1 and cyclin Y (CCNY) in promoting noncanonical Wnt signaling. In HCC cells, we found PFTK1 forms a direct complex with CCNY, and together readily upregulate key components of Wnt signaling (Dvl2 and Naked1… CONTINUE READING

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