PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity

  title={PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity},
  author={Cheng Zhang and Shehzahdi Shebbrin Moonshi and Yanxiao Han and Simon Puttick and Hui Peng and Bryan John Abel Magoling and James C. Reid and Stefano Bernardi and Debra J. Searles and Petr Kr{\'a}l and Andrew K. Whittaker},
19F magnetic resonance imaging (MRI) is a powerful noninvasive imaging technique with demonstrated potential for the detection of important diseases. The major challenge in the design of 19F MRI agents is signal attenuation caused by the reduced solubility and segmental mobility of probes with high numbers of fluorine atoms. Careful choice of the fluorinated moiety is required to maintain image quality at the fluorine contents required for high imaging sensitivity. Here we report the synthesis… 

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