PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity

@article{Zhang2017PFPEBasedP1,
  title={PFPE-Based Polymeric 19F MRI Agents: A New Class of Contrast Agents with Outstanding Sensitivity},
  author={Cheng Zhang and Shehzahdi Shebbrin Moonshi and Yanxiao Han and Simon Puttick and Hui Peng and Bryan John Abel Magoling and James C. Reid and Stefano Bernardi and Debra J. Searles and Petr Kr{\'a}l and Andrew K. Whittaker},
  journal={Macromolecules},
  year={2017},
  volume={50},
  pages={5953-5963}
}
19F magnetic resonance imaging (MRI) is a powerful noninvasive imaging technique with demonstrated potential for the detection of important diseases. The major challenge in the design of 19F MRI agents is signal attenuation caused by the reduced solubility and segmental mobility of probes with high numbers of fluorine atoms. Careful choice of the fluorinated moiety is required to maintain image quality at the fluorine contents required for high imaging sensitivity. Here we report the synthesis… 

Figures and Tables from this paper

Enhanced Performance of Polymeric 19F MRI Contrast Agents through Incorporation of Highly Water-Soluble Monomer MSEA
TLDR
The synthesis and characterization of a series of polymeric 19F MRI contrast agents with high fluorine content are reported by copolymerizing the well-known fluorinated monomer 2,2,2-trifluoroethyl acrylate (TFEA) with a highly water-soluble monomers 2-(methylsulfinyl)ethyl acylate (MSEA) using RAFT polymerization.
A Multifunctional Contrast Agent for 19F-Based Magnetic Resonance Imaging.
TLDR
The design and preparation of a set of water-compatible fluorine-rich polymers as contrast agents that can enhance the effectiveness of 19F-based MRI are detailed and it is found that controlling the polymer stoichiometry and introducing additional segmental mobility enhance the NMR signals and narrow the peak profile.
Fluorinated Water-Soluble Poly(2-oxazoline)s as Highly Sensitive 19F MRI Contrast Agents
TLDR
The diagnostic potential of the new CAs was demonstrated by a successful in vivo F-19 MRI visualization of the selected fluorinated polymer in rats, and all CAs were found to be noncytotoxic for HeLa cells in vitro.
Partially fluorinated copolymers as oxygen sensitive 19F MRI agents.
TLDR
High-performance highly fluorinated monomers are reported that provide a platform to realize water-soluble, partially fluorinated copolymers as 19 F MRI agents with the required sensitivity to quantify solution oxygenation at clinically relevant magnetic field strengths.
A Hyperfluorinated Hydrophilic Molecule for Aqueous 19F MRI Contrast Media
Fluorine-19 (19F) magnetic resonance imaging (MRI) has the potential for a wide range of in vivo applications but is limited by lack of flexibility in exogenous probe formulation. Most 19F MRI probes
High F-Content Perfluoropolyether-Based Nanoparticles for Targeted Detection of Breast Cancer by 19F Magnetic Resonance and Optical Imaging.
TLDR
This report of the synthesis of polymeric aptamer-conjugated PFPE-based 19F MRI CAs with high fluorine content demonstrates that these NPs are exciting candidates for detecting diseases with high imaging sensitivity.
Fluorine polymer probes for magnetic resonance imaging: quo vadis?
TLDR
The chemical development, up to the first imaging applications, of these promising fluorine probes, including injectable polymers that form depots that are intended for possible use in cancer therapy are discussed.
A unique 19F MRI agent for the tracking of non phagocytic cells in vivo.
TLDR
Preliminary in vivo data demonstrate that labelled cells can be readily detected within a short acquisition scan period (12 minutes), and these copolymers show outstanding potential for 19F MRI cellular tracking and for quantification of non-phagocytic and therapeutically-relevant cells in vivo.
Tumor micro-environment sensitive 19F-magnetic resonance imaging in vivo
...
...

References

SHOWING 1-10 OF 43 REFERENCES
Polymeric 19F MRI agents responsive to reactive oxygen species
Medical imaging agents that can report on the biological state are attracting increasing interest. Here we report the development of novel 19F polymeric imaging agents that are activated by reactive
Multifunctional hyperbranched polymers for CT/19F MRI bimodal molecular imaging
To develop novel contrast agents for bimodal molecular imaging, we report here the design and synthesis of multifunctional hyperbranched polymers containing iodine and fluorine and their application
(19)F Magnetic Resonance Imaging Signals from Peptide Amphiphile Nanostructures Are Strongly Affected by Their Shape.
TLDR
This discovery identifies a strategy to design supramolecular, self-assembling contrast agents for (19)F MRI that can spatially map physiologically relevant changes in pH using changes in morphology.
Synthesis and evaluation of partly fluorinated block copolymers as MRI imaging agents.
TLDR
It was found that methacrylate polymers show systematically lower signal intensity than acrylatepolymers, related to the presence of a population of nuclear spins having very short T2 relaxation times that cannot be detected under high-resolution NMR and MRI conditions.
pH-responsive star polymer nanoparticles: potential 19F MRI contrast agents for tumour-selective imaging
Star polymers with a branched core and hydrophilic arms were synthesized by reversible addition–fragmentation chain transfer (RAFT) polymerization as pH-responsive 19F magnetic resonance imaging
Ion-responsive 19F MRI contrast agents for the detection of cancer cells
TLDR
High-resolution NMR and molecular dynamics study of conformational changes of ion-responsive 19F copolymers of oligo(ethylene glycol) methyl ether methacrylate and 2,2,2-trifluoroethyl acrylate in the presence of salt shows that further separation of OEGMA and TFEA segments and closer association of O EGMA side chain were observed with the addition of NaCl.
Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging.
TLDR
The use of supramolecular organic nanoparticles to detect specific proteins by (19)F-based MRI in an off/on mode with recognition-driven disassembly of nanoprobes for a turn-on ( 19)F signal is unprecedented and may extend the use of (19]F MRI for specific protein imaging.
Synthesis and evaluation of partly fluorinated polyelectrolytes as components in 19F MRI-detectable nanoparticles
A series of partly fluorinated polyelectrolytes were synthesized by transition metal mediated living radical polymerization and evaluated for their applicability as corona-forming components in 19F
Segmented Highly Branched Copolymers: Rationally Designed Macromolecules for Improved and Tunable (19)F MRI.
TLDR
The (19)F NMR properties were strongly affected by the sequence distribution of the fluorinated monomers, the type of polymer backbone and the degree of branching, and as a result, SHBPs consisting of statistical copolymeric segments of acrylate units were identified as excellent candidates for imaging.
A Symmetrical Fluorous Dendron‐Cyanine Dye‐Conjugated Bimodal Nanoprobe for Quantitative 19F MRI and NIR Fluorescence Bioimaging
TLDR
Results show that this bimodal imaging nanoprobe presents high correlation of 19F MR signal and NIR fluorescence intensity in vitro and in vivo, and can hold great potential for quantitative and sensitive multi‐modal molecular imaging.
...
...