PFOS prenatal exposure induce mitochondrial injury and gene expression change in hearts of weaned SD rats.

@article{Xia2011PFOSPE,
  title={PFOS prenatal exposure induce mitochondrial injury and gene expression change in hearts of weaned SD rats.},
  author={Wei Xia and Yanjian Wan and Yuan-yuan Li and Huaicai Zeng and Ziquan Lv and Gengqi Li and Zhengzheng Wei and Shun-qing Xu},
  journal={Toxicology},
  year={2011},
  volume={282 1-2},
  pages={
          23-9
        }
}
Xenobiotics exposure in early life may have adverse effects on animals' development through mitochondrial injury or dysfunction. The current study demonstrated the possibility of cardiac mitochondrial injury in prenatal PFOS-exposed weaned rat heart. Pregnant Sprague-Dawley (SD) rats were exposed to perfluorooctane sulfonate (PFOS) at doses of 0.1, 0.6 and 2.0 mg/kg/d and 0.05% Tween 80 as control by gavage from gestation days 2-21. The dams were allowed to give nature delivery and then heart… CONTINUE READING
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