PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.

Abstract

The Aurora family of highly related serine/threonine kinases plays a key role in the regulation of mitosis. Aurora1 and Aurora2 play important but distinct roles in the G(2) and M phases of the cell cycle and are essential for proper chromosome segregation and cell division. Overexpression and amplification of Aurora2 have been reported in different tumor… (More)
DOI: 10.1158/1535-7163.MCT-09-0915

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Cite this paper

@article{Jani2010PF03814735AO, title={PF-03814735, an orally bioavailable small molecule aurora kinase inhibitor for cancer therapy.}, author={Jitesh P. Jani and Joel T Arcari and Vincent Bernardo and Samit K. Bhattacharya and David Briere and Bruce D. Cohen and Kevin Coleman and James G. Christensen and Erling O Emerson and Amy B Jakowski and Kenneth E. Hook and Gerrit Los and James D Moyer and Ingrid M Pruimboom-Brees and Leslie R Pustilnik and Ann Marie K Rossi and Stefan J. Steyn and Chunyan Su and Konstantinos E Tsaparikos and Donn G. Wishka and Kwansik Yoon and John L Jakubczak}, journal={Molecular cancer therapeutics}, year={2010}, volume={9 4}, pages={883-94} }