PEX5 and Ubiquitin Dynamics on Mammalian Peroxisome Membranes

@inproceedings{Brown2014PEX5AU,
  title={PEX5 and Ubiquitin Dynamics on Mammalian Peroxisome Membranes},
  author={Aidan I. Brown and Peter Kijun Kim and Andrew D. Rutenberg},
  booktitle={PLoS Computational Biology},
  year={2014}
}
Peroxisomes are membrane-bound organelles within eukaryotic cells that post-translationally import folded proteins into their matrix. Matrix protein import requires a shuttle receptor protein, usually PEX5, that cycles through docking with the peroxisomal membrane, ubiquitination, and export back into the cytosol followed by deubiquitination. Matrix proteins associate with PEX5 in the cytosol and are translocated into the peroxisome lumen during the PEX5 cycle. This cargo translocation step is… CONTINUE READING
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