PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.

@article{Gould2014PETSI,
  title={PET studies in nonhuman primate models of cocaine abuse: translational research related to vulnerability and neuroadaptations.},
  author={Robert Wayne Gould and Angela N. Duke and Michael A. Nader},
  journal={Neuropharmacology},
  year={2014},
  volume={84},
  pages={138-51}
}
The current review highlights the utility of positron emission tomography (PET) imaging to study the neurobiological substrates underlying vulnerability to cocaine addiction and subsequent adaptations following chronic cocaine self-administration in nonhuman primate models of cocaine abuse. Environmental (e.g., social rank) and sex-specific influences on dopaminergic function and sensitivity to the reinforcing effects of cocaine are discussed. Cocaine-related cognitive deficits have been… CONTINUE READING