PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.

@article{Wong2008PETOH,
  title={PET of hypoxia and perfusion with 62Cu-ATSM and 62Cu-PTSM using a 62Zn/62Cu generator.},
  author={Terence Z. Wong and Jeffrey L. Lacy and Neil A. Petry and Thomas C. Hawk and Thomas A. Sporn and Mark W. Dewhirst and Gordana Vlahovi{\'c}},
  journal={AJR. American journal of roentgenology},
  year={2008},
  volume={190 2},
  pages={427-32}
}
OBJECTIVE Copper-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM) and copper-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) are being studied as potential markers of hypoxia and perfusion, respectively. The use of short-lived radionuclides (e.g., 62Cu) has advantages for clinical PET, including a lower radiation dose than long-lived radionuclides and serial imaging capability. A 62Zn/62Cu microgenerator and rapid synthesis kits now provide a practical means of producing 62Cu-PTSM and… CONTINUE READING
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