PET of EGFR expression with an 18F-labeled affibody molecule.

  title={PET of EGFR expression with an 18F-labeled affibody molecule.},
  author={Zheng Miao and Gang Ren and Hongguang Liu and Shibo Qi and Song Wu and Zhen Cheng},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  volume={53 7},
UNLABELLED Epidermal growth factor receptor (EGFR) is often overexpressed in a variety of human cancers, and its expression is associated with poor prognosis for many cancer types. However, an accurate technique to noninvasively image EGFR expression in vivo is not available in the clinical setting. In this research, an Affibody analog, anti-EGFR Ac-Cys-Z(EGFR:1907), was successfully site-specifically (18)F-labeled for PET of EGFR expression. METHODS The prosthetic group N-[2-(4-(18)F… CONTINUE READING
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