PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog.

@article{Thakur2004PETIO,
  title={PET imaging of oncogene overexpression using 64Cu-vasoactive intestinal peptide (VIP) analog: comparison with 99mTc-VIP analog.},
  author={Mathew L. Thakur and Mohan R Aruva and Jean Gari{\'e}py and Paul D. Acton and Satish Rattan and Shyam Prasad and Eric Wickstrom and Abass Alavi},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2004},
  volume={45 8},
  pages={1381-9}
}
UNLABELLED The purpose of this study was to assess the feasibility of PET imaging of oncogene VPAC1 receptors overexpressed in human breast cancer cells. METHODS Vasoactive intestinal peptide (VIP) analog (TP3982) was synthesized to harbor a carboxy-terminus lysine (Lys) residue separated from VIP-asparagine (Asn(28)) by 4-aminobutyric acid (Aba) as a spacer. Lys was derivatized with diaminopropionic acid coupled to a pair of dibenzoylthioglycolic acid residues as protecting groups. The… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Development of a peptide by phage display for SPECT imaging of resistance-susceptible breast cancer.

American journal of nuclear medicine and molecular imaging • 2014
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…