PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys.

@article{Czoty2007PETIO,
  title={PET imaging of dopamine D2 receptor and transporter availability during acquisition of cocaine self-administration in rhesus monkeys.},
  author={Paul W. Czoty and H. Donald Gage and Susan H. Nader and Beth A. Reboussin and Michael C. Bounds and Michael A. Nader},
  journal={Journal of addiction medicine},
  year={2007},
  volume={1 1},
  pages={33-9}
}
Previous studies have demonstrated that cocaine use alters availability of brain dopamine D2 receptors (D2R) and transporters (DAT). The present study examined the effects of low doses of cocaine on this neuroadaptation. Using positron emission tomography (PET), D2R and DAT availability in the caudate nucleus (Cd), putamen (Pt), anterior cingulate cortex (ACC), and amygdala (AMY) were assessed before and after monkeys acquired cocaine self-administration. Twelve rhesus monkeys were trained to… CONTINUE READING