PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2

@article{Gao2011PETIO,
  title={PET imaging of angiogenesis after myocardial infarction/reperfusion using a one-step labeled integrin-targeted tracer 18F-AlF-NOTA-PRGD2},
  author={Haokao Gao and Lixin Lang and Ning Guo and Feng Yi Cao and Qimeng Quan and Shuo Hu and Dale O. Kiesewetter and Gang Niu and Xiaoyuan Chen},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2011},
  volume={39},
  pages={683-692}
}
The αvβ3 integrin represents a potential target for noninvasive imaging of angiogenesis. The purpose of this study was to evaluate a novel one-step labeled integrin αvβ3-targeting positron emission tomography (PET) probe, 18F-AlF-NOTA-PRGD2, for angiogenesis imaging in a myocardial infarction/reperfusion (MI/R) animal model. Male Sprague-Dawley rats underwent 45-min transient left coronary artery occlusion followed by reperfusion. The myocardial infarction was confirmed by ECG, 18F… CONTINUE READING

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