PET imaging of Oatp-mediated hepatobiliary transport of [(11)C] rosuvastatin in the rat.

@article{He2014PETIO,
  title={PET imaging of Oatp-mediated hepatobiliary transport of [(11)C] rosuvastatin in the rat.},
  author={Jiake He and Yonghao Yu and Bhagwat Prasad and Jeanne M. Link and Robert S. Miyaoka and Xi-jing Chen and JashvantD. Unadkat},
  journal={Molecular pharmaceutics},
  year={2014},
  volume={11 8},
  pages={
          2745-54
        }
}
UNLABELLED A novel positron emission tomography (PET) tracer, [(11)C]-rosuvastatin (RSV), was developed to dynamically and noninvasively measure hepatobiliary transport and tissue distribution of [(11)C]-RSV in rats. METHODS Male Sprague-Dawley rats were administered either an Oatp inhibitor, rifampin (RIF, 40 mg/kg iv bolus plus 1.85 mg/min/kg iv infusion, n = 3), or the corresponding vehicle (saline, n = 3) for at least 90 min. Then, while these infusions were ongoing, the animals received… CONTINUE READING
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