PET imaging of HER1-expressing xenografts in mice with 86Y-CHX-A″-DTPA-cetuximab

Abstract

Cetuximab is a recombinant, human/mouse chimeric IgG1 monoclonal antibody that binds to the epidermal growth factor receptor (EGFR/HER1). Cetuximab is approved for the treatment of patients with HER1-expressing metastatic colorectal cancer. Limitations in currently reported radiolabeled cetuximab for PET applications prompted the development of 86Y-CHX-A… (More)
DOI: 10.1007/s00259-009-1370-z

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