PET evidence of central GABAergic changes in stiff-person syndrome.

@article{Perani2007PETEO,
  title={PET evidence of central GABAergic changes in stiff-person syndrome.},
  author={Daniela Perani and Valentina Garibotto and Andrea Panzacchi and Rosa Maria Moresco and Paola Ortelli and Massimo Corbo and Ferruccio Fazio and Franco Folli},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2007},
  volume={22 7},
  pages={1030-3}
}
We measured expression of central nervous system GABA-A receptors with (11)C-flumazenil ((11)C-FMZ) and PET in two subjects with stiff person syndrome (SPS). We found reduced (11)C-FMZ binding potential (BP) in motor-premotor cortex, and increased (11)C-FMZ BP in the cerebellar nuclei. This is the first in vivo PET evidence of central GABA-A receptors… CONTINUE READING