PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.

  title={PET demonstrates reduced dopamine transporter expression in PD with dyskinesias.},
  author={Andr{\'e} Ribeiro Troiano and Ra{\'u}l de la Fuente-Fern{\'a}ndez and Vesna Sossi and Michael Schulzer and Edwin Mak and Thomas J. Ruth and A John Stoessl},
  volume={72 14},
OBJECTIVE Dyskinesias are common in Parkinson disease (PD). Prior investigations suggest that dopamine (DA) terminals compensate for abnormal DA transmission. We verified whether similar adaptations could be related to the development of treatment-related complications. METHODS Thirty-six patients with PD with motor fluctuations were assessed with PET using [(11)C]-d-threo-methylphenidate (MP) and [(11)C]-(+/-) dihydrotetrabenazine (DTBZ). The expression of DA transporter relative to DA nerve… CONTINUE READING


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pamine transporter relation to dopamine turnover in Parkinson ’ s disease : a positron emission tomography study

  • V Sossi, R delaFuente-Fernandez, M Schulzer
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