PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo.

@article{Mairinger2011PETAS,
  title={PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo.},
  author={Severin Mairinger and Thomas Erker and Markus Muller and Oliver Langer},
  journal={Current drug metabolism},
  year={2011},
  volume={12 8},
  pages={774-92}
}
Adenosine triphosphate-binding cassette (ABC) transporters, such as P-glycoprotein (Pgp, ABCB1), breast cancer resistance protein (BCRP, ABCG2) and multidrug resistance-associated proteins (MRPs) are expressed in high concentrations at various physiological barriers (e.g. blood-brain barrier, blood-testis barrier, blood-tumor barrier), where they impede the tissue accumulation of various drugs by active efflux transport. Changes in ABC transporter expression and function are thought to be… CONTINUE READING