PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments.

@article{Blykers2015PETIO,
  title={PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments.},
  author={Anneleen Blykers and Steve Schoonooghe and Catarina Xavier and Kevin D'hoe and Damya Laoui and Matthias D'huyvetter and Ilse Vaneycken and Frederik Cleeren and Guy Bormans and Johannes Heemskerk and Geert Raes and Patrick de Baetselier and Tony Lahoutte and Nick Devoogdt and Jo A. van Ginderachter and Vicky Caveliers},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2015},
  volume={56 8},
  pages={1265-71}
}
UNLABELLED Tumor-associated macrophages constitute a major component of the stroma of solid tumors, encompassing distinct subpopulations with different characteristics and functions. We aimed to identify M2-oriented tumor-supporting macrophages within the tumor microenvironment as indicators of cancer progression and prognosis, using PET imaging. This can be realized by designing (18)F-labeled camelid single-domain antibody fragments (sdAbs) specifically targeting the macrophage mannose… CONTINUE READING
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