PET [11C]DASB imaging of serotonin transporters in patients with alcoholism.

  title={PET [11C]DASB imaging of serotonin transporters in patients with alcoholism.},
  author={Amira K Brown and David Ted George and Masahiro Fujita and Jeih-San Liow and Masanori Ichise and Joseph R Hibbeln and Subroto Ghose and Janet L Sangare and Daniel Hommer and Robert B. Innis},
  journal={Alcoholism, clinical and experimental research},
  volume={31 1},
OBJECTIVE Alcoholism and aggression have each been associated with neurochemical measurements suggestive of decreased serotonin synaptic transmission. We measured densities of the serotonin transporter (SERT) in a moderate-sized sample of alcoholic patients who were assessed for aggressive characteristics. METHODS Thirty alcoholic inpatients and 18 healthy controls received a PET scan with [(11)C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile. The alcoholic inpatients were… CONTINUE READING

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