PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles.

@article{Lee2008PETMRIDT,
  title={PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)-conjugated radiolabeled iron oxide nanoparticles.},
  author={Ha-young Lee and Zibo Li and Kai Jen Chen and Andrew R. Hsu and Chenjie Xu and Jin Rong Xie and Shouheng Sun and Xiaoyuan Chen},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2008},
  volume={49 8},
  pages={
          1371-9
        }
}
UNLABELLED The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for PET and MRI scans of tumor integrin alphavbeta3 expression. METHODS Polyaspartic acid (PASP)-coated IO (PASP-IO) nanoparticles were synthesized using a coprecipitation method, and particle size and magnetic properties were measured. A phantom study was used to assess the efficacy of PASP-IO as a T2-weighted MRI contrast agent. PASP-IO nanoparticles with surface amino groups were coupled… CONTINUE READING

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