PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.

@article{Senders2018PETMRIO,
  title={PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis.},
  author={Max L. Senders and Xuchu Que and Young Seok Cho and Calvin Yeang and Hannah Groenen and Francois Fay and Claudia Calcagno and Anu E Meerwaldt and Simone Green and Phuong Miu and Mark E. Lobatto and Thomas Reiner and Zahi A. Fayad and Joseph L. Witztum and Willem J M Mulder and Carlos P{\'e}rez-Medina and Sotirios Tsimikas},
  journal={Journal of the American College of Cardiology},
  year={2018},
  volume={71 3},
  pages={
          321-335
        }
}
BACKGROUND Oxidation-specific epitopes (OSEs) are proinflammatory, and elevated levels in plasma predict cardiovascular events. OBJECTIVES The purpose of this study was to develop novel positron emission tomography (PET) probes to noninvasively image OSE-rich lesions. METHODS An antigen-binding fragment (Fab) antibody library was constructed from human fetal cord blood. After multiple rounds of screening against malondialdehyde-acetaldehyde (MAA) epitopes, the Fab LA25 containing minimal… CONTINUE READING