PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.

@article{Wang2015PESTDM,
  title={PEST domain mutations in Notch receptors comprise an oncogenic driver segment in triple-negative breast cancer sensitive to a γ-secretase inhibitor.},
  author={Kai Wang and Qin Zhang and Danan Li and Keith Ching and Cathy Q Zhang and Xianxian Zheng and Mark Ozeck and Stephanie T. Shi and Xiaorong Li and Hui Wang and Paul A. Rejto and James G. Christensen and Peter Olson},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2015},
  volume={21 6},
  pages={1487-96}
}
PURPOSE To identify and characterize novel, activating mutations in Notch receptors in breast cancer and to determine response to the gamma secretase inhibitor (GSI) PF-03084014. EXPERIMENTAL DESIGN We used several computational approaches, including novel algorithms, to analyze next-generation sequencing data and related omic datasets from The Cancer Genome Atlas (TCGA) breast cancer cohort. Patient-derived xenograft (PDX) models were sequenced, and Notch-mutant models were treated with PF… CONTINUE READING
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