PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons

@inproceedings{Zhu2016PERKRG,
  title={PERK regulates Gq protein-coupled intracellular Ca2+ dynamics in primary cortical neurons},
  author={Siying Zhu and Barbara C. McGrath and Yuting Bai and Xin Tang and Douglas R Cavener},
  booktitle={Molecular Brain},
  year={2016}
}
PERK (EIF2AK3) is an ER-resident eIF2α kinase required for behavioral flexibility and metabotropic glutamate receptor-dependent long-term depression via its translational control. Motivated by the recent discoveries that PERK regulates Ca2+ dynamics in insulin-secreting β-cells underlying glucose-stimulated insulin secretion, and modulates Ca2+ signals-dependent working memory, we explored the role of PERK in regulating Gq protein-coupled Ca2+ dynamics in pyramidal neurons. We found that acute… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 3 times over the past 90 days. VIEW TWEETS
4 Citations
55 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Similar Papers

Loading similar papers…