PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

@inproceedings{BobrovnikovaMarjon2010PERKPC,
  title={PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage},
  author={Ekaterina Bobrovnikova-Marjon and Christina Grigoriadou and Dariusz Pytel and Fang Zhang and Jiangbin Ye and Constantinos Koumenis and Douglas R Cavener and J Alan Diehl},
  booktitle={Oncogene},
  year={2010}
}
To proliferate and expand in an environment with limited nutrients, cancer cells co-opt cellular regulatory pathways that facilitate adaptation and thereby maintain tumor growth and survival potential. The endoplasmic reticulum (ER) is uniquely positioned to sense nutrient deprivation stress and subsequently engage signaling pathways that promote adaptive strategies. As such, components of the ER stress-signaling pathway represent potential antineoplastic targets. However, recent investigations… CONTINUE READING

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