PERK-ing up autophagy during MYC-induced tumorigenesis.

  title={PERK-ing up autophagy during MYC-induced tumorigenesis.},
  author={Souvik Dey and Feven Tameire and Constantinos Koumenis},
  volume={9 4},
Stress in the tumor microenvironment in the form of hypoxia and low glucose/amino acid levels activates the evolutionarily conserved cellular adaptation program called the unfolded protein response (UPR) promoting cell survival in such conditions. Our recent studies showed that cell autonomous stress such as activation of the proto-oncogene MYC/c-Myc, can also trigger the UPR and induce endoplasmic reticulum (ER) stress-mediated autophagy. Amelioration of ER stress or autophagy enhances cancer… CONTINUE READING


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