PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver.

@article{Li2003PERKEK,
  title={PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver.},
  author={Yulin Li and Kaori Iida and Jeff O'Neil and Peichuan Zhang and Sheng'ai Li and Ami T. Frank and Aryn Gabai and Frank Zambito and S Q Liang and Clifford J. Rosen and Douglas R Cavener},
  journal={Endocrinology},
  year={2003},
  volume={144 8},
  pages={3505-13}
}
Humans afflicted with the Wolcott-Rallison syndrome and mice deficient for PERK (pancreatic endoplasmic reticulum eIF2alpha kinase) show severe postnatal growth retardation. In mice, growth retardation in Perk-/- mutants is manifested within the first few days of neonatal development. Growth parameters of Perk-/- mice, including comparison of body weight to length and organ weights, are consistent with proportional dwarfism. Tibia growth plates exhibited a reduction in proliferative and… CONTINUE READING

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