PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.

@article{Meares2014PERKdependentAO,
  title={PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation.},
  author={Gordon P. Meares and Yudong Liu and Rajani Rajbhandari and Hongwei Qin and Susan E Nozell and James A. Mobley and John A Corbett and Etty Nadia Benveniste},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 20},
  pages={3911-25}
}
Neuroinflammation and endoplasmic reticulum (ER) stress are associated with many neurological diseases. Here, we have examined the interaction between ER stress and JAK/STAT-dependent inflammation in glial cells. We show that ER stress is present in the central nervous system (CNS) concomitant with inflammation and astrogliosis in the multiple sclerosis (MS) mouse model of experimental autoimmune encephalomyelitis (EAE). Astrocytes do not easily succumb to ER stress but rather activate an… CONTINUE READING
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