PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice.

@article{Oishi2009PERIOD2IA,
  title={PERIOD2 is a circadian negative regulator of PAI-1 gene expression in mice.},
  author={Katsutaka Oishi and Koyomi Miyazaki and Daisuke Uchida and Naoki Ohkura and Miyuki Wakabayashi and Ryosuke Doi and Juzo Matsuda and Norio Ishida},
  journal={Journal of molecular and cellular cardiology},
  year={2009},
  volume={46 4},
  pages={545-52}
}
An increased level of obesity-induced plasma plasminogen activator inhibitor-1 (PAI-1) is considered a risk factor for cardiovascular disease. To determine whether the circadian clock component PERIOD2 (PER2) is involved in the regulation of PAI-1 gene expression, we performed transient transfection assays in vitro, and generated transgenic (Tg) mice overexpressing PER2. We then compared PAI-1 expression in Tg and wild-type (WT) mice with or without obesity induced by a high-fat/high-sucrose… CONTINUE READING

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