PER2 controls lipid metabolism by direct regulation of PPARγ.

@article{Grimaldi2010PER2CL,
  title={PER2 controls lipid metabolism by direct regulation of PPARγ.},
  author={Benedetto Grimaldi and Marina M Bellet and Sayako Katada and Giuseppe Astarita and Jun Hirayama and Rajesh Haresh Amin and James Gerard Granneman and Daniele Piomelli and Todd P. Leff and Paolo Sassone-Corsi},
  journal={Cell metabolism},
  year={2010},
  volume={12 5},
  pages={
          509-20
        }
}
Accumulating evidence highlights intriguing interplays between circadian and metabolic pathways. We show that PER2 directly and specifically represses PPARγ, a nuclear receptor critical in adipogenesis, insulin sensitivity, and inflammatory response. PER2-deficient mice display altered lipid metabolism with drastic reduction of total triacylglycerol and nonesterified fatty acids. PER2 exerts its inhibitory function by blocking PPARγ recruitment to target promoters and thereby transcriptional… CONTINUE READING
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