PER protein interactions and temperature compensation of a circadian clock in Drosophila.

Abstract

The periods of circadian clocks are relatively temperature-insensitive. Indeed, the perL mutation in the Drosophila melanogaster period gene, a central component of the clock, affects temperature compensation as well as period length. The per protein (PER) contains a dimerization domain (PAS) within which the perL mutation is located. Amino acid substitutions at the perL position rendered PER dimerization temperature-sensitive. In addition, another region of PER interacted with PAS, and the perL mutation enhanced this putative intramolecular interaction, which may compete with PAS-PAS intermolecular interactions. Therefore, temperature compensation of circadian period in Drosophila may be due in part to temperature-independent PER activity, which is based on competition between inter- and intramolecular interactions with similar temperature coefficients.

Statistics

02040'96'98'00'02'04'06'08'10'12'14'16
Citations per Year

168 Citations

Semantic Scholar estimates that this publication has 168 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Huang1995PERPI, title={PER protein interactions and temperature compensation of a circadian clock in Drosophila.}, author={Zuoshi J. Huang and Kathryn D. Curtin and Michael Rosbash}, journal={Science}, year={1995}, volume={267 5201}, pages={1169-72} }