PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double‐blind, vehicle‐controlled, multicentre, phase IIa study

@article{Siller2009PEP005M,
  title={PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: Results of a randomized, double‐blind, vehicle‐controlled, multicentre, phase IIa study},
  author={G. Siller and K. Gebauer and P. Welburn and Janelle Katsamas and S. Ogbourne},
  journal={Australasian Journal of Dermatology},
  year={2009},
  volume={50}
}
The sap of the plant Euphorbia peplus is a traditional remedy for skin conditions, including actinic keratosis. The active constituent of the sap is ingenol mebutate (ingenol‐3‐angelate), formerly known as PEP005. This randomized, double‐blind, vehicle‐controlled, phase IIa study investigated the safety (and secondarily the efficacy) of two applications of ingenol mebutate gel in 58 patients with biopsy‐confirmed actinic keratosis. Five preselected lesions were treated with ingenol mebutate gel… Expand
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