PENFLURIDOL (R 16 341) AS A MAINTENANCE THERAPY IN CHRONIC PSYCHOTIC PATIENTS: A DOUBLE‐BLIND CLINICAL EVALUATION

@article{Roelofs1974PENFLURIDOL1,
  title={PENFLURIDOL (R 16 341) AS A MAINTENANCE THERAPY IN CHRONIC PSYCHOTIC PATIENTS: A DOUBLE‐BLIND CLINICAL EVALUATION},
  author={G. A. Roelofs},
  journal={Acta Psychiatrica Scandinavica},
  year={1974},
  volume={50}
}
  • G. Roelofs
  • Published 1 April 1974
  • Medicine, Psychology
  • Acta Psychiatrica Scandinavica
A double‐blind, 6‐month trial of penfluridol and placebo was conducted in 15 chronic psychotic patients in the age range of 25–64 years. The patients, who had been well controlled with penfluridol for several months, were divided into two comparable groups with seven patients receiving penfluridol and eight receiving placebo. Dexetimide and other non‐psychotropic drugs already taken before the trial were continued. Each patient was assessed before and after 1, 2, 4 and 6 months of treatment… 
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11 Citations

11 Citations

A DOUBLE‐BLIND CLINICAL EVALUATION OF PENFLURIDOL (R 16 341) AS A MAINTENANCE THERAPY IN SCHIZOPHRENIA

Twenty‐one female schizophrenics (age range 34–74 years) were included in a clinical study assessing the effectiveness of penfluridol as a basic maintenance therapy. At the start of the study, the…

PERORAL AND PARENTERAL ADMINISTRATION OF LONG‐ACTING NEUROLEPTICS: A DOUBLE‐BLIND STUDY OF PENFLURIDOL COMPARED TO FLUPENTHIXOL DECANOATE IN THE TREATMENT OF SCHIZOPHRENIA

Fifty‐six out of 60 schizophrenic patients completed a double‐blind study of two long‐acting neuroleptics, penfluridol (peroral) and flupenthixol decanoate (parenteral). Half of the patients were on…

Controlled trial of penfluridol and thiothixene in the maintenance treatment of chronic schizophrenic syndromes

In a controlled trial of penfluridol and thiothixene as maintenance drugs in patients with chronic schizophrenic syndromes, some improvement over previous neuroleptics was seen with both drugs. This…

Penfluridol for schizophrenia.

BACKGROUND Penfluridol, available since 1970, is an unusual long acting oral antipsychotic agent for the treatment of schizophrenia. It may be considered a depot medication as it is administered once…

The Use of Continuous Treatment Versus Placebo or Intermittent Treatment Strategies in Stabilized Patients with Schizophrenia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials with First- and Second-Generation Antipsychotics

TLDR
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Depot Antipsychotic Drugs

SummaryThe pharmacokinetics of depot antipsychotic medications are such that an intramuscular injection given at intervals of from 1 to 4 weeks will produce adequate plasma concentrations that are…

Weekly Supervised Administration of Oral Antipsychotics: An Alternative to Long-Acting Injections?

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To be suitable for once-weekly administration as an oral formulation, an antipsychotic needs to have a sufficiently long duration of action and to be well tolerated in high doses.

Maintenance treatment with antipsychotic drugs for schizophrenia.

TLDR
The efficacy of antipsychotic drugs for maintenance treatment in schizophrenia was clear and the results of the primary outcome were robust in a number of subgroup, meta-regression and analyses.

A historical review of placebo-controlled, relapse prevention trials in schizophrenia: The loss of clinical equipoise

Maintenance treatment with antipsychotic drugs for schizophrenia.

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The efficacy of antipsychotic drugs for maintenance treatment in schizophrenia was clear and hospitalisation was reduced and underpowered data revealed no evidence of a difference between groups for the outcome 'Death due to suicide'.

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