PELP1: A novel therapeutic target for hormonal cancers.

  title={PELP1: A novel therapeutic target for hormonal cancers.},
  author={Dimple Chakravarty and Rajeshwar Rao Tekmal and Ratna K Vadlamudi},
  journal={IUBMB life},
  volume={62 3},
Recent studies implicate that the estrogen receptor (ER) coregulator proline-, glutamic acid-, and leucine-rich protein (PELP) 1 as playing critical roles in ER-genomic, ER-nongenomic, and ER-signaling cross talk with growth factor signaling pathways. PELP1 expression is deregulated in hormonal cancers and recent studies further elucidated the molecular mechanisms by which PELP1 regulates hormone therapy response. Although PELP1 is important for normal functions of the ER, the possibility to… CONTINUE READING