PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection.

@article{Kievit2009PEIPEGChitosanCC,
  title={PEI-PEG-Chitosan Copolymer Coated Iron Oxide Nanoparticles for Safe Gene Delivery: synthesis, complexation, and transfection.},
  author={Forrest M Kievit and Omid Veiseh and Narayan Bhattarai and Chen Fang and Jonathan W Gunn and Donghoon Lee and Richard G. Ellenbogen and James M. Olson and Miqin Zhang},
  journal={Advanced functional materials},
  year={2009},
  volume={19 14},
  pages={2244-2251}
}
Gene therapy offers the potential of mediating disease through modification of specific cellular functions of target cells. However, effective transport of nucleic acids to target cells with minimal side effects remains a challenge despite the use of unique viral and non-viral delivery approaches. Here we present a non-viral nanoparticle gene carrier that… CONTINUE READING