PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice

@article{Peng2011PEGylationOA,
  title={PEGylation of a Factor VIII–Phosphatidylinositol Complex: Pharmacokinetics and Immunogenicity in Hemophilia A Mice},
  author={Aaron Peng and Matthew Pierson Kosloski and Genki Nakamura and Hong Ding and Sathy V Balu-iyer},
  journal={The AAPS Journal},
  year={2011},
  volume={14},
  pages={35-42}
}
Hemophilia A is an X-linked bleeding disorder caused by the deficiency of factor VIII (FVIII). Exogenous FVIII is administered therapeutically, and due to a short half-life, frequent infusions are often required. Fifteen to thirty-five percent of severe hemophilia A patients develop inhibitory antibodies toward FVIII that complicate clinical management of the disease. Previously, we used phosphatidylinositol (PI) containing lipidic nanoparticles to improve the therapeutic efficacy of… CONTINUE READING
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