PEGylation of Interferon-β-1a

@article{Kieseier2012PEGylationOI,
  title={PEGylation of Interferon-$\beta$-1a},
  author={Bernd C. Kieseier and Peter A. Calabresi},
  journal={CNS Drugs},
  year={2012},
  volume={26},
  pages={205-214}
}
Achieving optimal patient benefit from biological therapies can be hindered by drug instability, rapid clearance requiring frequent dosing or potential immune reactions. One strategy for addressing these challenges is drug modification through PEGylation, a well established process by which one or more molecules of polyethylene glycol (PEG) are covalently attached to a biological or small-molecule drug, effectively transforming it into a therapy with improved pharmacokinetic and pharmacodynamic… 
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46 Citations
Background Citations
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Methods Citations
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Results Citations
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46 Citations

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Citation Type

An update on the evidence base for peginterferon β1a in the treatment of relapsing–remitting multiple sclerosis
TLDR
Peginterferon β1a administered every 2 weeks resulted in a more robust treatment effect on ARR, sustained disability progression and magnetic resonance imaging endpoints than peginterferonβ1a every 4 weeks, and an adverse-effect profile similar to other interferon α formulations coupled with the advantage of a significant reduction in the number of injections, could lead to improved long-term adherence to peginerferonbeta.
Incidence, characterization, and clinical impact analysis of peginterferon beta1a immunogenicity in patients with multiple sclerosis in the ADVANCE trial
TLDR
The treatment effect of peginterferon beta1a in patients with relapsing–remitting MS is not expected to be attenuated by immunogenicity, although these analyses were limited by the low incidence of treatment-emergent antibodies.
COMPARE: Pharmacokinetic profiles of subcutaneous peginterferon beta‐1a and subcutaneous interferon beta‐1a over 2 weeks in healthy subjects
TLDR
Numerically lower frequencies and incidence rates of ISRs, headache, myalgia and chills were observed with s.c. peginterferon beta‐1a three times a week over 2 weeks, and a lower frequency of AEs.
Peginterferon beta-1a for the treatment of relapsing multiple sclerosis: A case series.
  • B. Hendin
  • Medicine
    Multiple sclerosis and related disorders
  • 2018
TLDR
With appropriate patient education and expectation setting regarding potential flu-like symptoms and injection-site reactions, peginterferon beta-1a may be a beneficial alternative for patients who prefer less frequent injections.
Pharmacokinetics, Pharmacodynamics, and Safety of Peginterferon Beta-Ia in Subjects with Normal or Impaired Renal Function
TLDR
The results do not warrant peginterferon beta‐1a dose adjustment in subjects with renal impairment and neopterin baseline, peak concentration, and AUC increased as renal function decreased.
Peginterferon Beta-1a: A Review of Its Use in Patients with Relapsing-Remitting Multiple Sclerosis
TLDR
Subcutaneous peginterferon beta-1a every 2 weeks extends the treatment options currently available for adults with RRMS, with the dosing regimen imparting potential compliance advantages over non-PEGylated interferon Beta formulations that require more frequent administration.
Advances in the treatment of relapsing–remitting multiple sclerosis: the role of pegylated interferon β-1a
TLDR
An overview of the role of IFN in the treatment of MS is provided and the available evidence for pegylated IFN therapy in MS is evaluated.
Glycoengineering of Interferon-β 1a Improves Its Biophysical and Pharmacokinetic Properties
TLDR
Hyperglycosylated rhIFn-β could be a biobetter version of rhIFN-β 1a with a potential for use as a drug against multiple sclerosis.
Peginterferon beta-1a in relapsing–remitting multiple sclerosis: a guide to its use in the EU
TLDR
Peginterferon beta-1a (Plegridy™) extends the options currently available to treat adults with relapsing–remitting multiple sclerosis (RRMS) and provides potential compliance advantages over non-pegylated interferonbeta formulations that require more frequent administration.
Second-generation immunotherapeutics in multiple sclerosis: can we discard their precursors?
TLDR
The shortcomings of the parent drugs are addressed, the pros and cons of the second-generation therapies are presented, and upcoming developments in the field of immunotherapy for multiple sclerosis are summarized.
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