PEGylating a bacteriophage endolysin inhibits its bactericidal activity

Abstract

Bacteriophage endolysins (lysins) bind to a cell wall substrate and cleave peptidoglycan, resulting in hypotonic lysis of the phage-infected bacteria. When purified lysins are added externally to Gram-positive bacteria they mediate rapid death by the same mechanism. For this reason, novel therapeutic strategies have been developed using such enzybiotics… (More)
DOI: 10.1186/2191-0855-1-29

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@inproceedings{Resch2011PEGylatingAB, title={PEGylating a bacteriophage endolysin inhibits its bactericidal activity}, author={Gr{\'e}gory Resch and Philippe Moreillon and Vincent A. Fischetti}, booktitle={AMB Express}, year={2011} }