PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers.

@article{Li2001PEGylatedPN,
  title={PEGylated polycyanoacrylate nanoparticles as tumor necrosis factor-alpha carriers.},
  author={Yaping Li and Yunan Pei and Z H Zhou and Xiao Ye Zhang and Zheng Gu and Jieying Ding and Jing Jun Zhou and Xue jun Gao},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2001},
  volume={71 3},
  pages={287-96}
}
The aim of this study was to find an effective carrier for recombinant human tumor necrosis factor-alpha (rHuTNF-alpha). The influence of solvent systems containing poly(methoxy-polyethyleneglycol cyanoacrylate-co-n-hexadecyl cyanoacrylate) (PEGylated PHDCA) on the biological activity of rHuTNF-alpha was investigated. The PEGylated PHDCA nanoparticles loading rHuTNF-alpha were prepared with the double emulsion method. The influence of main experimental factors on the entrapment efficiency was… CONTINUE READING