PEGylated graphene oxide-mediated protein delivery for cell function regulation.

@article{Shen2012PEGylatedGO,
  title={PEGylated graphene oxide-mediated protein delivery for cell function regulation.},
  author={He Yong Shen and Min Liu and Huixin He and Liming Zhang and Jie Huang and Yu Chong and Jianwu Dai and Zhijun Zhang},
  journal={ACS applied materials & interfaces},
  year={2012},
  volume={4 11},
  pages={6317-23}
}
Delivery of proteins into cells may alter cellular functions as various proteins are involved in cellular signaling by activating or deactivating the corresponding pathways and, therefore, can be used in cancer therapy. In this study, we have demonstrated for the first time that PEGylated graphene oxide (GO) can be exploited as a nanovector for efficient delivery of proteins into cells. In this approach, GO was functionalized with amine-terminated 6-armed polyethylene glycol (PEG) molecules… CONTINUE READING