PEGylated cholecystokinin prolongs satiation in rats: dose dependency and receptor involvement.

@article{Verbaeys2007PEGylatedCP,
  title={PEGylated cholecystokinin prolongs satiation in rats: dose dependency and receptor involvement.},
  author={Isabelle Verbaeys and Fabi{\'a}n Le{\'o}n-Tamariz and Johan Buyse and Marcel De Cuyper and H Pottel and Maurits Van Boven and Marnix Cokelaere},
  journal={British journal of pharmacology},
  year={2007},
  volume={152 3},
  pages={
          396-403
        }
}
BACKGROUND AND PURPOSE Acute intraperitoneal (i.p.) administration of cholecystokinin (CCK) is known to induce a significant, but short-lasting, reduction in food intake, followed by recovery within hours. Therefore, we had covalently coupled CCK to a 10 kDa polyethylene glycol and showed that this conjugate, PEG-CCK(9), produced a significantly longer anorectic effect than unmodified CCK(9). The present study assessed the dose-dependency of this response and the effect of two selective CCK(1… CONTINUE READING
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