PEGylated cationic liposome-DNA complexation in brine is pathway-dependent.

@article{Silva2014PEGylatedCL,
  title={PEGylated cationic liposome-DNA complexation in brine is pathway-dependent.},
  author={Bruno F B Silva and Ramsey N. Majzoub and Chia-Ling Carynn Chan and Youli Li and Ulf Olsson and Cyrus R Safinya},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1838 1 Pt B},
  pages={
          398-412
        }
}
Cationic liposome-DNA (CL-DNA) complexes, are regarded as promising materials for safe and efficient delivery of genes for therapeutical applications. In order to be used in vivo, these complexes may be coated with a hydrophilic polymer (e.g. polyethylene-glycol, PEG) that provides steric stabilization towards adhesion of proteins and removal by the immune system. In this work we study the influence of the initial salt concentration (Cs) - which modulates the electrostatic interaction between… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 60 REFERENCES

Phase diagram

  • I. Koltover, T. Salditt, C. R. Safinya
  • stability, and overcharging of lamellar cationic…
  • 1999
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