PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization.

@article{SnchezLpez2016PEGylatedPN,
  title={PEGylated PLGA nanospheres optimized by design of experiments for ocular administration of dexibuprofen-in vitro, ex vivo and in vivo characterization.},
  author={Elena S{\'a}nchez-L{\'o}pez and Mar{\'i}a Antonia Egea and Amanda S. Cano and Marta Espina and Ana Cristina Calpena and Miren Ettcheto and Antoni Camins and E. Souto and Am{\'e}lia Maria Marinho de Morais e Silva and M. L. Garcia},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2016},
  volume={145},
  pages={241-250}
}
Dexibuprofen-loaded PEGylated PLGA nanospheres have been developed to improve the biopharmaceutical profile of the anti-inflammatory drug for ocular administration. Dexibuprofen is the active enantiomer of ibuprofen and therefore lower doses may be applied to achieve the same therapeutic level. According to this, two batches of nanospheres of different drug concentrations, 0.5 and 1.0mg/ml respectively, have been developed (the latter corresponding to the therapeutic ibuprofen concentration for… CONTINUE READING