PEGylated PLGA nanoparticles for the improved delivery of doxorubicin.

  title={PEGylated PLGA nanoparticles for the improved delivery of doxorubicin.},
  author={Jason Park and Peter M. Fong and Jing Lu and Kerry Russell and Carmen J Booth and W. Mark Saltzman and Tarek M. Fahmy},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={5 4},
UNLABELLED We hypothesize that the efficacy of doxorubicin (DOX) can be maximized and dose-limiting cardiotoxicity minimized by controlled release from PEGylated nanoparticles. To test this hypothesis, a unique surface modification technique was used to create PEGylated poly(lactic-co-glycolic acid) (PLGA) nanoparticles encapsulating DOX. An avidin-biotin coupling system was used to control poly(ethylene glycol) conjugation to the surface of PLGA nanoparticles, of diameter approximately 130 nm… CONTINUE READING


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