PEGylated Biodegradable Polyesters for PGSS Microparticles Formulation: Processability, Physical and Release Properties.

@article{Perinelli2016PEGylatedBP,
  title={PEGylated Biodegradable Polyesters for PGSS Microparticles Formulation: Processability, Physical and Release Properties.},
  author={Diego Romano Perinelli and Marco Cespi and Giulia Bonacucina and Andrew Naylor and M Whitaker and Jenny Ka-Wing Lam and Steve M Howdle and Luca Casettari and G. Palmieri},
  journal={Current drug delivery},
  year={2016},
  volume={13 5},
  pages={673-81}
}
BACKGROUND Particles from Gas Saturated Solution (PGSS) is an emergent method that employs supercritical carbon dioxide (scCO2) to produce microparticles. It is suitable for encapsulating biologically active compounds including therapeutic peptides and proteins. Poly(lactide acid) (PLA) and/or poly(lactic-coglycolic acid) (PLGA) are the most commonly used materials in PGSS, due to their good processability in scCO2. Previous studies demonstrated that the properties of the microparticles can be… CONTINUE READING