PEGylated Adenoviruses for Gene Delivery to the Intestinal Epithelium by the Oral Route

  title={PEGylated Adenoviruses for Gene Delivery to the Intestinal Epithelium by the Oral Route},
  author={Xuan Cheng and Xin Ming and Maria A. Croyle},
  journal={Pharmaceutical Research},
Purpose. Adenoviruses are being developed for diseases of the gastrointestinal tract. Several in vitro assays were used to predict stability of PEGylated adenovirus along the GI tract and determine in vivo gene transfer after oral administration. Methods. Recombinant adenovirus was modified with monomethoxypoly(ethylene) glycols activated by cyanuric chloride, succinimidyl succinate, and tresyl chloride. Transduction efficiency was assessed on Caco-2 cells. In vitro stability of viruses in… CONTINUE READING
13 Citations
41 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 13 extracted citations


Publications referenced by this paper.
Showing 1-10 of 41 references

The Laboratory Rat (G

  • P. E. Sharp, M. C. La Regina
  • J. Krinke, ed.),
  • 2000
Highly Influential
3 Excerpts

Development of a stable adenoviral vector formulation

  • D. K. Hoganson, J. C. Ma, +5 authors M. J. D’Andrea
  • Bioprocessing
  • 2002
1 Excerpt

PEGylation of first-generation recombinant adenoviruses achieves significant gene expression upon intravenous re-administration

  • M. A. Croyle, N. Chirmule, Y. Zhang, J. M. Wilson
  • Hum. Gene Ther
  • 2002
2 Excerpts

Similar Papers

Loading similar papers…