PEG-variant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration.

@article{Tziampazis2000PEGvariantBA,
  title={PEG-variant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration.},
  author={Evangelos Tziampazis and Joachim Kohn and Prabhas V. Moghe},
  journal={Biomaterials},
  year={2000},
  volume={21 5},
  pages={511-20}
}
Our study focused on the role of poly(ethylene glycol) (PEG) in actively regulating the biological responsiveness of protein-adsorbed biomaterials. To this end, we designed PEG-variant biomaterials from a family of tyrosine/PEG-derived polycarbonates to present surfaces ranging from low to intermediate levels of PEG concentration, below the PEG level requisite for complete abolition of protein adsorption. We analyzed the effect of PEG concentration on the amount, conformation and bioactivity of… CONTINUE READING