PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction

@inproceedings{Zheng2012PEGnanolizedUS,
  title={PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction},
  author={Shanyuan Zheng and Xiaoling Li and Yibo Zhang and Qiang Xie and Y. B. Wong and Wenjie Zheng and Tianfeng Chen},
  booktitle={International journal of nanomedicine},
  year={2012}
}
Gray selenium (Se) is one of the most widely used Se sources with very limited biocompatibility and bioactivity. In the present study, a simple method for the preparation of ultrasmall selenium nanoparticles (SeNPs) through direct nanolization of gray selenium by polyethylene glycol (PEG) was demonstrated. Monodisperse and homogeneous PEG-SeNPs with ultrasmall diameters were successfully prepared under optimized conditions. The products were characterized using various microscopic and… CONTINUE READING