PEG-modulated column chromatography for purification of recombinant adeno-associated virus serotype 9.

@article{Zhou2011PEGmodulatedCC,
  title={PEG-modulated column chromatography for purification of recombinant adeno-associated virus serotype 9.},
  author={Jingmin Zhou and Xiao Yang and J. F. Wright and K. A. High and Linda Couto and Guang Qu},
  journal={Journal of virological methods},
  year={2011},
  volume={173 1},
  pages={99-107}
}
Column chromatography has been described for purification of recombinant adeno-associated viral vectors (rAAV) serotypes 1, 2, 5, 6 and 8. Some of these purification processes have been used in manufacturing pre-clinical grade and clinical grade rAAV vectors. Recently, recombinant AAV9 has been reported to be highly efficient in transducing cardiac muscle in animal models. Systemic or cardiac gene delivery and other applications may require large quantities of rAAV9 vectors, thus a scalable… CONTINUE READING
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