PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination.

@article{Oberoi2016PEGML,
  title={PEG modified liposomes containing CRX-601 adjuvant in combination with methylglycol chitosan enhance the murine sublingual immune response to influenza vaccination.},
  author={Hardeep Singh Oberoi and Yvonne M. Yorgensen and Audrey Morasse and Jay T Evans and David J Burkhart},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2016},
  volume={223},
  pages={64-74}
}
The mucosa is the primary point of entry for pathogens making it an important vaccination site to produce a protective mucosal immune response. While the sublingual (SL) mucosa presents several barriers to vaccine penetration, its unique anatomy and physiology makes it one of the best options for mucosal vaccination. Efficient and directed delivery of adjuvants and antigens to appropriate immune mediators in the SL tissue will aid in development of effective SL vaccines against infectious… CONTINUE READING
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