PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release.

@article{Bhattarai2005PEGgraftedCA,
  title={PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release.},
  author={Narayan Bhattarai and Hassna Rehman Ramay and Jonathan W Gunn and Frederick A. Matsen and Miqin Zhang},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2005},
  volume={103 3},
  pages={609-24}
}
Thermosensitive polymer hydrogels that undergo a sol-to-gel transition in response to temperature changes are of great interest in therapeutic delivery and tissue engineering as injectable depot systems. A chitosan-based, injectable thermogel was prepared by grafting an appropriate amount of PEG onto the chitosan backbone and studied for drug release in vitro using bovine serum albumin (BSA) as a model protein. When more than approximately 40 wt.% of PEG was grafted to chitosan chains via… CONTINUE READING

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