PEG-PCL-DEX polymersome-protamine vector as an efficient gene delivery system via PEG-guided self-assembly.

Abstract

AIM The nonviral carrier system based on the triblock copolymer PEG-PCL-DEX (PPD) and protamine was developed for nucleic acid delivery. MATERIALS & METHODS Self-assembly occurred in the PEG continuous phase to form 'dextran-interior' polymersomes. siRNA can be condensed by protamine and encapsulated into PPD polymersomes in order to form the PPD… (More)
DOI: 10.2217/nnm.13.83

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